Consult a health care practitioner before use if you are taking other medications or natural health products, as berberine is known to affect the metabolism of numerous drugs. If you have conditions like diabetes, hypoglycemia, low blood pressure, liver disease, or cardiovascular issues, seek medical advice before starting. If you experience sweating, paleness, chills, headaches, dizziness, and/or confusion, discontinue immediately and consult a health care professional, as these could be signs of low blood sugar.